Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
30 results
JACC. Cardiovascular interventions, Volume 16, Issue 14, 21 3 2023, Pages 1813-1815 Retrograde Use of Intravascular Lithotripsy in Anterograde Uncrossable In-Stent Chronic Occlusion: "Retrotripsy Technique". Montero-Cabezas JM, Al Amri I, van Oort MJH, Bingen BO, Scherptong RWC, van der Kley F
Cited 1 times since 2021 (0.3 per year) source: EuropePMC
European heart journal. Digital health, Volume 2, Issue 3, 11 2 2021, Pages 511-520 Development of a patient-oriented Hololens application to illustrate the function of medication after myocardial infarction. Hilt AD, Hierck BP, Eijkenduijn J, Wesselius FJ, Albayrak A, Melles M, Schalij MJ, Scherptong RWC
Aims: Statin treatment is one of the hallmarks of secondary prevention after myocardial infarction. Adherence to statins tends to be difficult and can be improved by patient education. Novel technologies such as mixed reality (MR) expand the possibilities to support this process. To assess if an MR medication-application supports patient education focused on function of statins after myocardial infarction. Methods and results: A human-centred design-approach was used to develop an MR statin tool... Abstract
Cited 9 times since 2020 (2.3 per year) source: EuropePMC
JMIR human factors, Volume 7, Issue 2, 23 4 2020, Pages e17147 Perspectives of Patients and Professionals on Information and Education After Myocardial Infarction With Insight for Mixed Reality Implementation: Cross-Sectional Interview Study. Hilt AD, Mamaqi Kapllani K, Hierck BP, Kemp AC, Albayrak A, Melles M, Schalij MJ, Scherptong RWC
Background: Patient education is crucial in the secondary prevention of cardiovascular disease. Novel technologies such as augmented reality or mixed reality expand the possibilities for providing visual support in this process. Mixed reality creates interactive digital three-dimensional (3D) projections overlaying virtual objects on the real-world environment. While augmented reality only overlays objects, mixed reality not just overlays but anchors virtual objects to the real world. However, r... Abstract
Cited 11 times since 2020 (2.8 per year) source: EuropePMC
Cardiology and therapy, Volume 9, Issue 2, 20 3 2020, Pages 307-321 Optical Coherence Tomography: Current Applications for the Assessment of Coronary Artery Disease and Guidance of Percutaneous Coronary Interventions. Oosterveer TTM, van der Meer SM, Scherptong RWC, Jukema JW
Introduction: Coronary angiography (CAG) is the standard modality for assessment of coronary stenoses and intraprocedural guidance of percutaneous coronary interventions (PCI). However, the limitations of CAG are well recognized. Intracoronary imaging (ICI) can potentially overcome these limitations. Intravascular ultrasound (IVUS) and optical coherence tomography (OCT) are the main ICI techniques utilized in clinical practice. Aim: This narrative literature review addresses the current clinical... Abstract
Cited 1 times since 2019 (0.2 per year) source: EuropePMC
Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc, Volume 25, Issue 3, 10 2 2019, Pages e12722 An initial exploration of subtraction electrocardiography to detect myocardial ischemia in the prehospital setting. Ter Haar CC, Peters RJG, Bosch J, Sbrollini A, Gripenstedt S, Adams R, Bleijenberg E, Kirchhof CJHJ, Alizadeh Dehnavi R, Burattini L, de Winter RJ, Macfarlane PW, Postema PG, Man S, Scherptong RWC, Schalij MJ, Maan AC, Swenne CA
Background: In the prehospital triage of patients presenting with symptoms suggestive of acute myocardial ischemia, reliable myocardial ischemia detection in the electrocardiogram (ECG) is pivotal. Due to large interindividual variability and overlap between ischemic and nonischemic ECG-patterns, incorporation of a previous elective (reference) ECG may improve accuracy. The aim of the current study was to explore the potential value of serial ECG analysis using subtraction electrocardiography. M... Abstract
Cited 6 times since 2019 (1.1 per year) source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 27, Issue 1, 1 1 2019, Pages 18-23 Expectations and perceived barriers to widespread implementation of e‑Health in cardiology practice: Results from a national survey in the Netherlands. Treskes RW, Wildbergh TX, Schalij MJ, Scherptong RWC
Introduction: Expectations of physicians concerning e‑Health and perceived barriers to implementation in clinical practice are scarcely reported in the literature. The purpose of this study was to assess these aspects of cardiovascular e‑Health. Methods: A survey was sent to members of the Netherlands Society of Cardiology. In total, the questionnaire contained 30 questions about five topics: personal use of smartphones, digital communication between respondents and patients, current e‑Health im... Abstract
Cited 13 times since 2018 (2.4 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 105, Issue 10, 10 2 2018, Pages 790-796 Long-term outcome after atrial correction for transposition of the great arteries. Couperus LE, Vliegen HW, Zandstra TE, Kiès P, Jongbloed MRM, Holman ER, Zeppenfeld K, Hazekamp MG, Schalij MJ, Scherptong RWC
Objective: This study assessed adult survival and morbidity patterns in patients who underwent atrial correction according to Mustard or Senning for transposition of the great arteries (TGA). Methods: In 76 adult patients with TGA (59% male) after atrial correction, long-term survival and morbidity were investigated in three periods: early (30 years postoperatively). Results: The Mustard technique was performed in 41 (54%) patients, and the Senning technique was performed in 35 (46%) patients ag... Abstract
Cited 1 times since 2018 (0.2 per year) source: EuropePMC
Heart, lung & circulation, Volume 28, Issue 6, 8 2 2018, Pages 893-900 Prognostic Importance of Increased Right Ventricular Afterload in Orthotopic Liver Transplantation Recipients With Endstage Cirrhosis. Couperus LE, Vliegen HW, Sorgdrager BJ, den Dulk AC, Beeres SLMA, Sarton EY, Dubbeld J, Schalij MJ, Jukema JW, van Hoek B, Scherptong RWC
Background: Severely increased right ventricular (RV) afterload is considered a contra-indication for orthotopic liver transplantation (OLT). This study assesses the effects of mildly increased RV afterload on long-term outcome after OLT in relation to RV function. Methods: 139 OLT recipients (53±12years, 76% male) were included. Preoperative RV afterload was assessed invasively or, if not available, echocardiographically and categorised as normal, high-normal (mean pulmonary artery pressure [PA... Abstract
Journal of electrocardiology, Volume 50, Issue 1, 8 2 2016, Pages 115-122 Detection of elevated pulmonary pressures by the ECG-derived ventricular gradient: A comparison of conversion matrices in patients with suspected pulmonary hypertension. Haeck ML, Kapel GF, Scherptong RW, Swenne CA, Maan AC, Bax JJ, Schalij MJ, Vliegen HW
Background: The aim was to assess the diagnostic value of the Inverse Dower (INVD)-derived vectorcardiogram (VCG) and the Kors-derived VCG to detect elevated systolic pulmonary artery pressure (SPAP) in suspected pulmonary hypertension (PH). Methods: In 132 patients, morphologic variables were evaluated by comparing the VCG parameters synthesized by INVD and Kors matrix. Comparison of the diagnostic accuracy of detecting SPAP ≥50mmHg between the matrices was performed by ROC curve analysis and l... Abstract
Cited 14 times since 2016 (1.7 per year) source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 50, Issue 3, 16 3 2016, Pages 456-463 Follow-up after tricuspid valve surgery in adult patients with systemic right ventricles. Koolbergen DR, Ahmed Y, Bouma BJ, Scherptong RW, Bruggemans EF, Vliegen HW, Holman ER, Mulder BJ, Hazekamp MG
Objectives: In patients with congenitally corrected transposition of the great arteries (ccTGA) or after atrial (Mustard or Senning) correction for transposition of the great arteries (acTGA), the right ventricle (RV) supports the systemic circulation. The tricuspid valve (TV) (systemic atrioventricular valve) is prone to regurgitation in these patients and this is associated with impending RV failure and decreased survival. This study evaluates mid-term functional improvements, echocardiographi... Abstract
Cited 2 times since 2015 (0.2 per year) source: EuropePMC
Journal of electrocardiology, Volume 49, Issue 1, 26 4 2015, Pages 60-68 Electrocardiographic detection of pulmonary hypertension in patients with systemic sclerosis using the ventricular gradient. Couperus LE, Vliegen HW, Henkens IR, Maan AC, Treskes RW, de Vries JK, Schouffoer AA, Swenne CA, Schalij MJ, Scherptong RW
Background: Pulmonary hypertension (PH) is a leading cause of death in systemic sclerosis (SSc) patients. The current study assessed the ability of the ECG-derived ventricular gradient (VG-RVPO) to detect PH and predict all-cause mortality in PH patients with subtypes of SSc differing in the extent of multi-organ involvement. Methods: ECGs were obtained from 196 patients with limited and 77 patients with diffuse SSc included from our screening programme on cardiac complications. The association... Abstract
Cited 14 times since 2015 (1.6 per year) source: EuropePMC
PloS one, Volume 10, Issue 9, 21 3 2015, Pages e0136025 Regional differences in WT-1 and Tcf21 expression during ventricular development: implications for myocardial compaction. Vicente-Steijn R, Scherptong RW, Kruithof BP, Duim SN, Goumans MJ, Wisse LJ, Zhou B, Pu WT, Poelmann RE, Schalij MJ, Tallquist MD, Gittenberger-de Groot AC, Jongbloed MR
Background: Morphological and functional differences of the right and left ventricle are apparent in the adult human heart. A differential contribution of cardiac fibroblasts and smooth muscle cells (populations of epicardium-derived cells) to each ventricle may account for part of the morphological-functional disparity. Here we studied the relation between epicardial derivatives and the development of compact ventricular myocardium. Results: Wildtype and Wt1CreERT2/+ reporter mice were used to... Abstract
Cited 28 times since 2012 (2.4 per year) source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 15, Issue 2, 28 4 2012, Pages 290-296 Incremental prognostic value of an abnormal baseline spatial QRS-T angle in chronic dialysis patients. de Bie MK, Koopman MG, Gaasbeek A, Dekker FW, Maan AC, Swenne CA, Scherptong RW, van Dessel PF, Wilde AA, Schalij MJ, Rabelink TJ, Jukema JW
Aims: In order to improve the abysmal outcome of dialysis patients, it is critical to identify patients with a high mortality risk. The spatial QRS-T angle, which can be easily calculated from the 12 lead electrocardiogram (ECG), might be useful in the prognostication in dialysis patients. The objective of this study was to establish the prognostic value of the spatial QRS-T angle. Methods and results: All patients who initiated dialysis therapy between 2002 and 2009 in the hospitals of Leiden (... Abstract
Cited 126 times since 2012 (10.7 per year) source: EuropePMC
Circulation. Cardiovascular imaging, Volume 5, Issue 5, 8 2 2012, Pages 628-636 Prognostic value of right ventricular longitudinal peak systolic strain in patients with pulmonary hypertension. Haeck ML, Scherptong RW, Marsan NA, Holman ER, Schalij MJ, Bax JJ, Vliegen HW, Delgado V
Background: Right ventricular (RV) function is an important prognostic marker in patients with pulmonary hypertension. The present evaluation assessed the prognostic value of RV longitudinal peak systolic strain (LPSS) in patients with pulmonary hypertension. Methods and results: A total of 150 patients with pulmonary hypertension of different etiologies (mean age, 59±15 years; 37.3% male) were evaluated. RV fractional area change and tricuspid annular plane systolic excursion index were evaluat... Abstract
Cited 24 times since 2012 (2 per year) source: EuropePMC
Developmental dynamics : an official publication of the American Association of Anatomists, Volume 241, Issue 9, 30 5 2012, Pages 1413-1422 Morphogenesis of outflow tract rotation during cardiac development: the pulmonary push concept. Scherptong RW, Jongbloed MR, Wisse LJ, Vicente-Steijn R, Bartelings MM, Poelmann RE, Schalij MJ, Gittenberger-De Groot AC
Background: Understanding of cardiac outflow tract (OFT) remodeling is essential to explain repositioning of the aorta and pulmonary orifice. In wild type embryos (E9.5-14.5), second heart field contribution (SHF) to the OFT was studied using expression patterns of Islet 1, Nkx2.5, MLC-2a, WT-1, and 3D-reconstructions. Abnormal remodeling was studied in VEGF120/120 embryos. Results: In wild type, Islet 1 and Nkx2.5 positive myocardial precursors formed an asymmetric elongated column almost exclu... Abstract
Cited 14 times since 2012 (1.2 per year) source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 25, Issue 6, 17 3 2012, Pages 674-681 Right ventricular longitudinal peak systolic strain measurements from the subcostal view in patients with suspected pulmonary hypertension: a feasibility study. Haeck ML, Scherptong RW, Antoni ML, Marsan NA, Vliegen HW, Holman ER, Schalij MJ, Bax JJ, Delgado V
Background: The assessment of right ventricular (RV) function with two-dimensional echocardiography can be challenging in patients with pulmonary hypertension, especially in those with chronic pulmonary disease. The aim of the present study was to evaluate the feasibility of measuring RV longitudinal peak systolic strain (LPSS) in the echocardiographic subcostal view in patients with suspected pulmonary hypertension. Methods: A total of 179 patients evaluated for pulmonary hypertension were incl... Abstract
Cited 8 times since 2012 (0.7 per year) source: EuropePMC
Journal of electrocardiology, Volume 45, Issue 3, 20 3 2012, Pages 312-318 Diagnosis and mortality prediction in pulmonary hypertension: the value of the electrocardiogram-derived ventricular gradient. Scherptong RW, Henkens IR, Kapel GF, Swenne CA, van Kralingen KW, Huisman MV, Schuerwegh AJ, Bax JJ, van der Wall EE, Schalij MJ, Vliegen HW
Purpose: The aim of this study was to investigate the use of the electrocardiogram-derived ventricular gradient, projected on the x-axis (VGx), for detection of pulmonary hypertension (PH) and for prediction of all-cause mortality in PH patients. Methods: In patients referred for PH screening (n = 216), the VGx was calculated semiautomatically from the electrocardiogram and was defined as abnormal when less than 24 mV · ms. The VGx of PH patients was compared with the VGx of patients without PH.... Abstract
Cited 60 times since 2011 (4.8 per year) source: EuropePMC
Arthritis and rheumatism, Volume 63, Issue 12, 1 1 2011, Pages 3969-3978 Left ventricular dysfunction assessed by speckle-tracking strain analysis in patients with systemic sclerosis: relationship to functional capacity and ventricular arrhythmias. Yiu KH, Schouffoer AA, Marsan NA, Ninaber MK, Stolk J, Vlieland TV, Scherptong RW, Delgado V, Holman ER, Tse HF, Huizinga TW, Bax JJ, Schuerwegh AJ
Objective: Systemic sclerosis (SSc) is a connective tissue disease characterized by vascular inflammation and fibrosis. Visceral involvement, including cardiac manifestations, can lead to severe clinical complications, such as congestive heart failure, arrhythmias, and sudden death. Conventional echocardiography parameters have limited sensitivity to detect subtle myocardial dysfunction in patients with SSc. The aim of this study was to assess, using novel speckle-tracking strain analysis, the p... Abstract
Cited 10 times since 2011 (0.8 per year) source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 24, Issue 12, 14 2 2011, Pages 1392-1399.e1 Biventricular performance in patients with marfan syndrome without significant valvular disease: comparison to normal subjects and longitudinal follow-up. Scherptong RW, Vliegen HW, van der Wall EE, Hilhorst-Hofstee Y, Bax JJ, Scholte AJ, Delgado V
Background: The presence and progressive nature of primary myocardial involvement in Marfan syndrome are debated. The aim of this study was to evaluate the clinical relevance of left ventricular (LV) and right ventricular (RV) strain in adult patients with Marfan syndrome without significant valvular disease. Methods: Adult patients with Marfan syndrome (n = 50; mean age, 35.2 ± 12.9 years) were followed prospectively. Echocardiography was performed annually and consisted of comprehensive assess... Abstract
Cited 12 times since 2011 (0.9 per year) source: EuropePMC
Journal of electrocardiology, Volume 44, Issue 4, 1 1 2011, Pages 410-415 Influence of the vectorcardiogram synthesis matrix on the power of the electrocardiogram-derived spatial QRS-T angle to predict arrhythmias in patients with ischemic heart disease and systolic left ventricular dysfunction. Man S, Algra AM, Schreurs CA, Borleffs CJ, Scherptong RW, van Erven L, van der Wall EE, Cannegieter SC, Schalij MJ, Swenne CA
Background and purpose: Several studies have demonstrated that the spatial mean QRS-T angle (SA) predicts cardiac events and mortality. Spatial mean QRS-T angle is a vectorcardiographic variable. Because in clinical practice, 12-lead standard electrocardiograms (ECGs) are recorded rather than vectorcardiograms (VCGs) according to Frank, VCGs are commonly obtained by synthesizing them from 12-lead ECGs, by using a VCG synthesis matrix. Hence, the thus computed SA is an estimate of the real SA mea... Abstract